X0306 4 2020-12-31 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001563584 LEONARD JOHN M C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET; SUITE 130 CAMBRIDGE MA 02139 1 1 0 0 President and CEO Common Stock 2020-12-31 4 M 0 14375 0.00 A 481727 D Common Stock 2021-01-05 4 S 0 6239 55.86 D 475488 D Common Stock 58415 I By Trust Stock Option (right to buy) 23.46 2020-12-31 4 A 0 28750 0.00 A 2020-12-31 2028-03-20 Common Stock 28750 28750 D Restricted Stock Unit (performance-based) 2020-12-31 4 A 0 14375 0.00 A 2020-12-31 Common Stock 14375 14375 D Restricted Stock Unit (performance-based) 2020-12-31 4 M 0 14375 0.00 D 2020-12-31 Common Stock 14375 0 D Shares sold in sell-to-cover transaction in order to satisfy withholding taxes to be paid upon the vesting of 14,375 performance-based restricted stock units ("PRSUs") on December 31, 2020. Shares held by the John M. Leonard 2015 Irrevocable Trust. On March 21, 2018, the reporting person was granted an option to purchase 86,250 shares of common stock pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan. The award had performance-based vesting, with one-third of the award vesting upon each achievement of three scientific and regulatory milestones through the calendar year 2020 (the "Performance Milestones"). On December 31, 2020, one of the Performance Milestones was achieved, resulting in the vesting of the option as to 28,750 shares. On March 21, 2018, the reporting person was granted 43,125 PRSUs pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan. Each PRSU represents a contingent right to receive one share of the Company's common stock upon vesting, with one-third of the PRSUs vesting upon each achievement of the Performance Milestones through the calendar year 2020. On December 31, 2020, one of the Performance Milestones was achieved, resulting in the vesting of 14,375 PRSUs. /s/Jose Rivera, Attorney-In-Fact 2021-01-05