Commitments and Contingencies (Details) - USD ($) $ in Thousands		1 Months Ended		12 Months Ended
	Jan. 01, 2022	Dec. 31, 2020	Aug. 31, 2012	Dec. 31, 2022	Dec. 31, 2019	Dec. 31, 2018
Contingencies and Commitments
Lease liability				$ 1,571
Right-of-use assets				1,227
Operating lease cost				300
Operating lease payments made				300
Operating Lease, Liability, Current				$ 340
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]				Accrued Liabilities, Current
Operating Lease, Liability, Noncurrent				$ 1,200
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]				Other Liabilities, Noncurrent
Pennsylvania | Office and laboratory space
Contingencies and Commitments
Lessee, Operating Lease, Existence of Option to Extend [true false]		true
Renewal term of operating lease		60 months
Incremental borrowing rate	9.75%
Remaining lease term				5 years 6 months
Pennsylvania | Office and laboratory space | Cumulative Effect, Period of Adoption, Adjustment [Member] | ASU 2016-02
Contingencies and Commitments
Lease liability	$ 1,800
Right-of-use assets	1,400
Deferred rent and tenant allowance netted off against right-of-use asset	$ 400
Umbrella Agreement with Aroa
Contingencies and Commitments
Payment for agreement			$ 4,000
Milestone payments related to research and development arrangements				$ 2,200
Fixed Cost Of Net Sales				27.00%
Purchase commitments				$ 1,000
Number of days for product supply				60 days
Percentage of products ordered to be supplied				75.00%
Royalty percentage of net sales				6.00%
Umbrella Agreement with Aroa | European territory
Contingencies and Commitments
Sales milestone payments due				$ 1,000
Purchase commitments due year Six				$ 1,000
Umbrella Agreement with Aroa | North American territory
Contingencies and Commitments
Sales milestone payment					$ 2,000	$ 1,000
Transfer Price For Product Produced				200.00%
Fixed Cost Of Net Sales				27.00%
Purchase commitments due year Six				$ 5,000
Other Suppliers for Exclusivity Rights [Member]
Contingencies and Commitments
Aggregate future payments				$ 20,700
Next Science
Contingencies and Commitments
Term of Contract				10 years
Collagen Matrix, Inc.
Contingencies and Commitments
Purchase commitments				$ 20,700
Term of Contract				9 years