Property and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Property and Equipment
Property and Equipment, Total	$ 4,943	$ 4,359
Less accumulated depreciation and amortization	(3,757)	(3,733)
Property and equipment, net	1,186	626
Depreciation expense	231	221	$ 278
Umbrella Agreement with Aroa
Property and Equipment
Property and Equipment, Total	200	200
Lab equipment
Property and Equipment
Property and Equipment, Total	$ 2,352	2,304
Estimated useful lives	5 years
Furniture and fixtures
Property and Equipment
Property and Equipment, Total	$ 242	118
Estimated useful lives	5 years
Computer equipment and software
Property and Equipment
Property and Equipment, Total	$ 468	577
Estimated useful lives	3 years
Leasehold improvements
Property and Equipment
Property and Equipment, Total	$ 1,881	$ 1,360

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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