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Property and Equipment (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Property and Equipment      
Property and Equipment, Total $ 4,359 $ 4,198  
Less accumulated depreciation and amortization (3,733) (3,521)  
Property and equipment, net 626 677  
Depreciation expense 221 278 $ 463
Umbrella Agreement with Aroa      
Property and Equipment      
Property and Equipment, Total 200 200  
Lab equipment      
Property and Equipment      
Property and Equipment, Total $ 2,304 2,250  
Estimated useful lives 5 years    
Furniture and fixtures      
Property and Equipment      
Property and Equipment, Total $ 118 112  
Estimated useful lives 5 years    
Computer equipment and software      
Property and Equipment      
Property and Equipment, Total $ 577 508  
Estimated useful lives 3 years    
Leasehold improvements      
Property and Equipment      
Property and Equipment, Total $ 1,360 $ 1,328