<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-05-18</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001014739</issuerCik>
        <issuerName>Option Care Health, Inc.</issuerName>
        <issuerTradingSymbol>OPCH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001561149</rptOwnerCik>
            <rptOwnerName>Bierbower Elizabeth D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OPTION CARE HEALTH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3000 LAKESIDE DRIVE, SUITE 300N</rptOwnerStreet2>
            <rptOwnerCity>BANNOCKBURN</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60015</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>Exhibit 24.1 Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Sarah Kim, attorney-in-fact for Ms. Bierbower</signatureName>
        <signatureDate>2022-05-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
