X0508 4 2024-04-01 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001560782 Daly James M C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 0 0 1 Common Stock 2024-04-01 4 M 0 20000 100.45 A 21198 D Common Stock 2024-04-01 4 M 0 1577 105.08 A 22775 D Common Stock 2024-04-01 4 S 0 6809 255.6366 D 15966 D Common Stock 2024-04-01 4 S 0 7401 256.5019 D 8565 D Common Stock 2024-04-01 4 S 0 3604 257.2981 D 4961 D Common Stock 2024-04-01 4 S 0 1460 258.2834 D 3501 D Common Stock 2024-04-01 4 S 0 200 259.11 D 3301 D Common Stock 2024-04-01 4 S 0 800 262.005 D 2501 D Common Stock 2024-04-01 4 S 0 178 263.3133 D 2323 D Common Stock 2024-04-01 4 S 0 351 264.8908 D 1972 D Common Stock 2024-04-01 4 S 0 500 265.486 D 1472 D Common Stock 2024-04-01 4 S 0 274 266.9052 D 1198 D Common Stock 2024-04-02 4 M 0 10912 105.08 A 12110 D Common Stock 2024-04-02 4 S 0 842 243.2559 D 11268 D Common Stock 2024-04-02 4 S 0 6279 244.1927 D 4989 D Common Stock 2024-04-02 4 S 0 2991 244.8946 D 1998 D Common Stock 2024-04-02 4 S 0 557 246.2958 D 1441 D Common Stock 2024-04-02 4 S 0 43 247.0342 D 1398 D Common Stock 2024-04-02 4 S 0 200 248.4508 D 1198 D Stock Option (Right to Buy) 100.45 2024-04-01 4 M 0 20000 0.00 D 2024-06-27 Common Stock 20000 0 D Stock Option (Right to Buy) 105.08 2024-04-01 4 M 0 1577 0.00 D 2024-06-17 Common Stock 1577 10912 D Stock Option (Right to Buy) 105.08 2024-04-02 4 M 0 10912 0.00 D 2024-06-17 Common Stock 10912 0 D (1) These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $255.01 to $256.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $256.01 to $257.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $257.01 to $258.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $258.01 to $258.93, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $259.10 to $259.12, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $261.59 to $262.15, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $263.09 to $264.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $264.11 to $265.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $265.35 to $265.64, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $266.73 to $267.21, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $242.58 to $243.56, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $243.60 to $244.58, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $244.61 to $245.53, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.62 to $246.54, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $246.72 to $247.24, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $247.96 to $248.72, inclusive. The shares underlying this option are fully vested and exercisable. Exhibit 24 - Power of Attorney /s/ Mardi Dier, as Attorney-in-Fact 2024-04-03