X0508 4 2024-05-23 false 0001560241 G1 Therapeutics, Inc. GTHX 0001978347 Thomas Monica R. 700 PARK OFFICES DRIVE, SUITE 200 RESEARCH TRIANGLE PARK NC 27709 false true false false Chief Legal & People Officer false Common Stock 2024-05-23 4 S false 5826.00 4.2678 D 109825.00 D The sales reported on this Form 4 represent shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sales were to satisfy tax withholding obligations to be funded by a "sell-to-cover" transaction and do not represent discretionary transactions by the Reporting Person. The price represents the weighted average price with a low of $4.215 and a high of $4.33. The Reporting Person undertakes to provide G1 Therapeutics, Inc., any security holder of G1 Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Represents (i) 6,850 shares of common stock; (ii) 37,500 RSUs from award granted on May 22, 2023; (iii) 27,975 RSUs from award granted on January 3, 2024; and (iv) 37,500 RSUs from award granted on March 20, 2024. /s / Sandi James, attorney-in-fact 2024-05-24