X0306 4 2023-01-03 false 0001560241 G1 Therapeutics, Inc. GTHX 0001783503 Avagliano Mark 700 PARK OFFICES DRIVE, SUITE 200 RESEARCH TRIANGLE PARK NC 27709 false true false false Chief Business Officer Common Stock 2023-01-03 4 A false 20600.00 0.00 A 42155.00 D Stock Options (Right to buy) 5.73 2023-01-03 4 A false 41100.00 0.00 A 2033-01-03 Common Stock 41100.00 41100.00 D Represents a restricted stock unit ("RSU") award that vests 25% on January 3, 2024 and 12.5% semi-annually thereafter, subject to the Reporting Person's continued service through each applicable vesting date. Each RSU represents a contingent right to receive one share of Issuer common stock. Represents (i) 7,055 shares of common stock; (ii) 5,500 RSUs from award granted on January 4, 2021; (iii) 9,000 RSUs from award granted on January 3, 2022; and (iv) 20,600 RSUs from award granted on January 3, 2023. The shares underlying this option vest as to 25% of the shares on January 3, 2024, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each applicable vesting date. Note: On January 3, 2023, the reporting person was also granted performance-based restricted stock units that are subject to material conditions beyond the reporting person's control, and, therefore, not considered derivative securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, and excluded from this report. /s/ James Stillman Hanson, attorney-in-fact 2023-01-05