X0306 4 2021-06-29 false 0001560241 G1 Therapeutics, Inc. GTHX 0001184420 RUDNICK SETH 700 PARK OFFICES DRIVE, SUITE 200 RESEARCH TRIANGLE PARK NC 27709 true false false false Common Stock 2021-06-29 4 M false 7969.00 0.39 A 12358.00 D Common Stock 2021-06-29 4 M false 2031.00 0.30 A 14389.00 D Common Stock 2021-06-29 4 S false 10000.00 22.3477 D 4389.00 D Common Stock 5266.00 I See Footnote Stock Option (Right to Buy) 0.30 2021-06-29 4 M false 2031.00 0.00 D 2025-02-27 Common Stock 2031.00 11859.00 D Stock Options (Right to Buy) 0.39 2021-06-29 4 M false 7969.00 0.00 D 2024-07-11 Common Stock 7969.00 0.00 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan. The price represents the weighted average price with a low of $22.11 and a high of $22.58. The Reporting Person undertakes to provide G1 Therapeutics, Inc., any security holder of G1 Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 2 to this Form 4. Represents 4,389 restricted stock units These shares are held in the Seth A. Rudnick 2014 GST Trust U/A Dated 03/01/2014 (the "Trust") for the benefit of the Reporting Person's heirs. The Reporting Person's spouse is trustee of the Trust. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. All shares underlying this option have vested. /s/ James Stillman Hanson, attorney-in-fact 2021-06-30