X0306 4 2021-06-17 false 0001560241 G1 Therapeutics, Inc. GTHX 0001184420 RUDNICK SETH 700 PARK OFFICES DRIVE, SUITE 200 RESEARCH TRIANGLE PARK NC 27709 true false false false Common Stock 2021-06-17 4 A false 4389.00 0.00 A 4389.00 D Common Stock 5266.00 I See Footnote Stock Options (Right to Buy) 21.97 2021-06-17 4 A false 19620.00 0.00 A 2031-06-17 Common Stock 19620.00 19620.00 D Represents a restricted stock unit ("RSU") award that vests in its entirety twelve months after June 17, 2021, subject to the Reporting Person's continued service as a director. Each RSU represents a contingent right to receive one share of Issuer common stock These shares are held in the Seth A. Rudnick 2014 GST Trust U/A Dated 03/01/2014 (the "Trust") for the benefit of the Reporting Person's heirs. The Reporting Person's spouse is trustee of the Trust. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. The shares underlying this option will vest in their entirety twelve months after June 17, 2021, subject to the Reporting Person's continued service as a director. /s/ James Stillman Hanson, attorney-in-fact 2021-06-21