X0306 4 2018-06-15 false 0001560241 G1 Therapeutics, Inc. GTHX 0001706853 Malik Rajesh C/O G1 THERAPEUTICS, 79 TW ALEXANDER DR. 4501 RESEARCH COMMONS, SUITE 100 RESEARCH TRIANGLE PARK NC 27709 false true false false Ch. Medical Officer & SVP R&D Common Stock 2018-06-15 4 M false 3776.00 4.17 A 12176.00 D Common Stock 2018-06-15 4 S false 3776.00 44.3131 D 8400.00 D Stock Options (Right to Buy) 4.17 2018-06-15 4 M false 3776.00 0.00 D 2026-05-10 Common Stock 3776.00 88175.00 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan. The price represents the weighted average price with a low of $44.00 and a high of $44.65. The Reporting Person undertakes to provide G1 Therapeutics, Inc., any security holder of G1 Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 2 to this Form 4. The shares underlying this option vested as to 25% of the shares on May 10, 2017, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each applicable vesting date. /s/ Peter N. Cunningham, attorney-in-fact 2018-06-18