X0306 4 2022-10-07 0 0001453593 Xtant Medical Holdings, Inc. XTNT 0001559834 Vizirgianakis Stavros G. 664 CRUISER LANE BELGRADE MT 59714 1 0 0 0 Common Stock, $0.000001 par value 2022-10-07 4 P 0 2264861 0.48 A 5850716 D Warrant 0.48 2022-10-07 4 P 0 566214 0 A 2022-10-07 2027-08-25 Common Stock 566214 566214 D These shares were issued in a second and final tranche of a private placement pursuant to a securities purchase agreement by and among Xtant Medical Holdings, Inc. and several accredited investors. Includes 70,776 shares to be issued upon vesting pursuant to a restricted stock unit award granted under the Xtant Medical Holdings, Inc. Amended and Restated 2018 Equity Incentive Plan, conditioned upon the reporting person remaining a director of Xtant through the vesting date. This warrant was issued in a second and final tranche of a private placement pursuant to the securities purchase agreement by and among Xtant Medical Holdings, Inc. and several accredited investors. This total does not include a warrant to purchase 878,770 shares of common stock issued on August 25, 2022. Such warrant was immediately exercisable as of the date of issuance and previously reported by the Reporting Person on a Form 4 filed with the Securities and Exchange Commission on August 26, 2022. /s/ Amy Culbert, attorney-in-fact 2022-10-11