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  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001834171</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001559720</own:issuerCik>
      <own:issuerName>Airbnb, Inc.</own:issuerName>
      <own:secFileNumber>001-39778</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>888 Brannan Street</com:street1>
        <com:city>San Francisco</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94103</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>415-728-0108</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Joseph Gebbia</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Director</own:relationshipToIssuer>
        <own:relationshipToIssuer>10% Shareholder</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>J.P. Morgan Securities LLC</own:name>
        <own:address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>2860</own:noOfUnitsSold>
      <own:aggregateMarketValue>378521</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>417930233</own:noOfUnitsOutstanding>
      <own:approxSaleDate>05/26/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>05/25/2026</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>RSU Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>2860</own:amountOfSecuritiesAcquired>
      <own:paymentDate>05/25/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>03/09/2026</own:saleDate>
      <own:amountOfSecuritiesSold>58000</own:amountOfSecuritiesSold>
      <own:grossProceeds>7613827</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>03/23/2026</own:saleDate>
      <own:amountOfSecuritiesSold>58000</own:amountOfSecuritiesSold>
      <own:grossProceeds>7685662</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>04/06/2026</own:saleDate>
      <own:amountOfSecuritiesSold>58000</own:amountOfSecuritiesSold>
      <own:grossProceeds>7317456</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>04/20/2026</own:saleDate>
      <own:amountOfSecuritiesSold>58000</own:amountOfSecuritiesSold>
      <own:grossProceeds>8270240</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>05/04/2026</own:saleDate>
      <own:amountOfSecuritiesSold>58000</own:amountOfSecuritiesSold>
      <own:grossProceeds>8141303</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Sycamore Trust</own:name>
        <own:address>
          <com:street1>C/o Airbnb, Inc.</com:street1>
          <com:street2>888 Brannan Street</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94103</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common Stock</own:securitiesClassTitle>
      <own:saleDate>05/18/2026</own:saleDate>
      <own:amountOfSecuritiesSold>54000</own:amountOfSecuritiesSold>
      <own:grossProceeds>7282706</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>05/26/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>08/29/2025</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Joseph Gebbia</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
