Consolidated Statement of Shareholders' Equity - USD ($) $ in Thousands	Total	Public Offering	At-The-Market Offering	Ordinary Shares	Ordinary Shares Public Offering	Ordinary Shares At-The-Market Offering	Additional Paid-in Capital	Additional Paid-in Capital Public Offering	Additional Paid-in Capital At-The-Market Offering	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2020				39,921,413
Beginning balance, value at Dec. 31, 2020	$ 184,006			$ 399			$ 966,636			$ (783,029)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share-Based Compensation	24,658						24,658
Issuance of ordinary shares upon exercise of stock options (in shares)				1,073,707
Issuance of ordinary shares upon exercise of stock options	15,557			$ 11			15,546
Issuance of ordinary shares (in shares)					4,025,000	1,640,174
Proceeds from issuance of ordinary shares in public offering, net		$ 78,049	$ 96,797		$ 40	$ 16		$ 78,009	$ 96,781
Net income (loss)	66,975									66,975
Ending balance (in shares) at Dec. 31, 2021				46,660,294
Ending balance, value at Dec. 31, 2021	466,042			$ 466			1,181,630			(716,054)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share-Based Compensation	31,322						31,322
Issuance of ordinary shares upon exercise of stock options (in shares)				1,282,086
Issuance of ordinary shares upon exercise of stock options	17,890			$ 14			17,876
Issuance of ordinary shares (in shares)					3,250,000	911,228
Proceeds from issuance of ordinary shares in public offering, net		172,363	51,374		$ 32	$ 9		172,331	51,365
Net income (loss)	(116,949)									(116,949)
Ending balance (in shares) at Dec. 31, 2022				52,103,608
Ending balance, value at Dec. 31, 2022	622,042			$ 521			1,454,524			(833,003)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share-Based Compensation	$ 40,914						40,914
Issuance of ordinary shares upon exercise of stock options (in shares)	1,135,302			1,135,302
Issuance of ordinary shares upon exercise of stock options	$ 21,457			$ 12			21,445
Issuance of ordinary shares (in shares)					395,096	42,361
Proceeds from issuance of ordinary shares in public offering, net		$ 20,909	$ 3,071		$ 4	$ 0		$ 20,905	$ 3,071
Issuance of ordinary shares upon vesting of restricted stock units (in shares)				5,750
Issuance of ordinary shares upon vesting of restricted stock units	0			$ 0			0
Net income (loss)	(147,028)									(147,028)
Ending balance (in shares) at Dec. 31, 2023				53,682,117
Ending balance, value at Dec. 31, 2023	$ 561,365			$ 537			$ 1,540,859			$ (980,031)