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Share-based Compensation - Share-based Compensation Plan - Option Activity (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2019
Options          
Options, outstanding beginning balance (in shares)     7,008,403    
Options, granted (in shares) 147,000 292,500 1,865,950 1,290,475  
Options, exercised (in shares)     (22,852)    
Options, forfeited (in shares)     (34,935)    
Options, expired (in shares)     (21,336)    
Options, outstanding ending balance (in shares) 8,795,230   8,795,230   7,008,403
Options, vested and expected to vest ending balance (in shares) 8,378,260   8,378,260    
Options, Vested (in shares)     4,859,859    
Weighted Average Exercise Price          
Weighted average exercise price, outstanding beginning balance (in dollars per share)     $ 23.34    
Weighted average exercise price, granted (in dollars per share)     11.94    
Weighted average exercise price, exercised (in dollars per share)     9.42    
Weighted average exercise price, forfeited (in dollars per share)     13.18    
Weighted average exercise price, expired (in dollars per share)     33.61    
Weighted average exercise price, outstanding ending balance (in dollars per share) $ 20.97   20.97   $ 23.34
Weighted average exercise price, vested and expected to vest, ending balance (in dollars per share) 21.34   21.34    
Weighted Average Exercise Price, vested (in dollars per shares) $ 25.93   $ 25.93    
Options, Additional Disclosures          
Weighted average remaining contractual term, outstanding (in years)     7 years 4 months 13 days   7 years 2 months 26 days
Weighted average remaining contractual term, vested and expected to vest (in years)     7 years 25 days    
Weighted Average Remaining Contractual Term, vested (in years)     6 years 3 months 3 days    
Aggregate intrinsic value, outstanding $ 1,994   $ 1,994   $ 11,901
Aggregate intrinsic value, vested and expected to vest, ending balance 1,986   1,986    
Aggregate intrinsic value, vested $ 1,918   $ 1,918