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Net Loss Per Ordinary Share - Ordinary Shares Equivalent Not Included in Diluted Net Loss Per Share (Detail) - shares
shares in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Options to purchase ordinary shares        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Stock options to purchase ordinary shares not included in diluted net loss per share (in shares) 8,795 7,185 8,795 7,185