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Net Loss Per Ordinary Share
9 Months Ended
Sep. 30, 2020
Earnings Per Share [Abstract]  
Net Income (Loss) Per Ordinary Share Net Loss Per Ordinary Share
Basic net income (loss) per ordinary share is calculated by dividing net income (loss) by the weighted-average number of ordinary shares outstanding during the period. Shares used in diluted net income per ordinary share would include the dilutive effect of ordinary shares potentially issuable upon the exercise of stock options outstanding. However, potentially issuable ordinary shares are not used in computing diluted net loss per ordinary share as their effect would be anti-dilutive due to the loss recorded during the three and nine months ended September 30, 2020, and 2019, and therefore diluted net loss per share is equal to basic net loss per share.
Net loss per ordinary share was determined as follows (in thousands, except per share amounts):
Three Months Ended
September 30,
Nine Months Ended
September 30,
2020201920202019
Numerator:
Net loss$(30,577)$(19,448)$(80,428)$(56,123)
Denominator:
Weighted-average ordinary shares outstanding39,917 39,897 39,912 39,877 
Net loss per share:
Basic and diluted net loss per share$(0.77)$(0.49)$(2.02)$(1.41)
The equivalent ordinary shares not included in diluted net loss per share because their effect would be anti-dilutive are as follows (in thousands):
 Three Months Ended
September 30,
Nine Months Ended
September 30,
 2020201920202019
Stock options to purchase ordinary shares8,795 7,185 8,795 7,185