Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Operating activities
Net loss	$ (7,150)us-gaap_NetIncomeLoss	$ (40,996)us-gaap_NetIncomeLoss	$ (41,411)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to cash used in operating activities:
Depreciation and amortization	743	660	468
Share-based compensation	5,597us-gaap_ShareBasedCompensation	3,128us-gaap_ShareBasedCompensation	6,098us-gaap_ShareBasedCompensation
Excess tax benefit from share-based award exercises	(242)	0	0
Deferred income taxes	(990)	(538)	0
Gain on disposal of fixed asset	(19)us-gaap_GainLossOnDispositionOfAssets1	(29)us-gaap_GainLossOnDispositionOfAssets1	0us-gaap_GainLossOnDispositionOfAssets1
Changes in operating assets and liabilities:
Receivable from Roche	(1,729)	0	0
Receivable from related party	28	165	(223)
Other assets	(2,352)	(721)	(467)
Accounts payable, accruals and other liabilities	5,431	6,233	(6,537)
Net cash used in operating activities	(683)	(32,098)	(42,072)
Investing activities
Purchases of property and equipment	(526)	(564)	(1,301)
Proceeds from disposal of fixed asset	27	29	0
Net cash used in investing activities	(499)	(535)	(1,301)
Financing activities
Proceeds from issuance of ordinary shares in public offering, net	117,348	84,534	0
Proceeds from issuance of ordinary shares to Elan	0	0	26,000
Proceeds from funding provided by Elan	0	0	145,233
Repayment of funding provided by Elan	0us-gaap_RepaymentsOfRelatedPartyDebt	0us-gaap_RepaymentsOfRelatedPartyDebt	(3,000)us-gaap_RepaymentsOfRelatedPartyDebt
Post separation adjustments to the funding provided by Elan	0	(84)	0
Proceeds from Stock Options Exercised	494	0	0
Excess tax benefit from share-based award exercises	242	0	0
Net cash provided by financing activities	118,084	84,450	168,233
Net increase in cash and cash equivalents	116,902	51,817	124,860
Cash and cash equivalents, beginning of the year	176,677	124,860	0
Cash and cash equivalents, end of the period	293,579	176,677	124,860
Supplemental disclosures of cash flow information
Cash paid for income taxes, net of refunds	1,588us-gaap_IncomeTaxesPaid	796us-gaap_IncomeTaxesPaid	0us-gaap_IncomeTaxesPaid
Supplemental disclosures of non cash investing and financing activities
Acquisition of property and equipment under accounts payable and accrued liabilities	0	26	0
Accrued deferred offering costs	0prta_AccruedOfferingCosts	82prta_AccruedOfferingCosts	0prta_AccruedOfferingCosts
Receivable from stock option exercises	$ 6prta_ReceivableStockOptionExercises	$ 0prta_ReceivableStockOptionExercises	$ 0prta_ReceivableStockOptionExercises

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The cash outflow for the payment of a long-term borrowing made from a related party where one party can exercise control or significant influence over another party; including affiliates, owners or officers and their immediate families, pension trusts, and so forth. Alternate caption: Payments for Advances from Affiliates.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 15

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3291-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Glossary Financing Activities

-URI http://asc.fasb.org/extlink&oid=6513228

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 28

-Subparagraph (a)

-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585

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