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Share-based Compensation - Share-based Compensation Plan - Option Activity (Detail) (USD $)
In Thousands, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]    
Options Exercised (69,244)us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised  
Amended and Restated 2012 Long Term Incentive Plan [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]    
Options, Outstanding beginning balance 1,973,500us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Options, granted 720,500us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
1,978,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
Options Exercised (69,244)us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Options, canceled (12,676)us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Options, Outstanding ending balance 2,612,080us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
1,973,500us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
Options, Vested and expected to vest ending balance 2,535,376us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Options Vested Outstanding Number 1,000,307prta_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedOutstandingNumber
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]    
Weighted Average Exercise Price, Outstanding beginning balance $ 7.50us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Exercise Price, Granted $ 28.02us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Exercise Price, Exercised $ 7.23us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Exercise Price, Canceled $ 15.97us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Exercise Price, Outstanding ending balance $ 13.13us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
$ 7.50us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
Weighted Average Exercise Price, Vested and expected to vest ending balance $ 13.00us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Exercise Price, Options Vested $ 7.35prta_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedPeriodWeightedAverageExercisePrice
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Weighted Average Remaining Contractual Life (Years), Outstanding ending balance 8 years 5 months 12 days 9 years 2 months 1 day
Weighted Average Remaining Contractual Life (Years), Vested and expected to vest ending balance 8 years 5 months 9 days  
Weighted Average Remaining Contractual Term, Vested Outstanding 8 years 1 month 24 days  
Aggregate Intrinsic Value, Outstanding ending balance $ 25,298us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
$ 37,528us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
Aggregate Intrinsic Value, Vested and expected to vest ending balance 24,788us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember
 
Aggregate Intrinsic Value, Options Vested $ 13,448prta_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueRelatedToVestedOptions
/ us-gaap_PlanNameAxis
= prta_TwoThousandTwelveLongTermIncentivePlanMember