<SEC-DOCUMENT>0001193125-14-247721-index.html : 20140627
<SEC-HEADER>0001193125-14-247721.hdr.sgml : 20140627
<ACCEPTANCE-DATETIME>20140624205415
ACCESSION NUMBER:		0001193125-14-247721
CONFORMED SUBMISSION TYPE:	S-3MEF
PUBLIC DOCUMENT COUNT:		6
<REFERENCE-462B>333-196965
FILED AS OF DATE:		20140624
DATE AS OF CHANGE:		20140624
EFFECTIVENESS DATE:		20140624

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Prothena Corp plc
		CENTRAL INDEX KEY:			0001559053
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-197006
		FILM NUMBER:		14938566

	BUSINESS ADDRESS:	
		STREET 1:		25-28 NORTH WALL QUAY
		CITY:			DUBLIN
		STATE:			L2
		ZIP:			DUBLIN 1
		BUSINESS PHONE:		650-615-2119

	MAIL ADDRESS:	
		STREET 1:		25-28 NORTH WALL QUAY
		CITY:			DUBLIN
		STATE:			L2
		ZIP:			DUBLIN 1

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Neotope Corp Ltd
		DATE OF NAME CHANGE:	20120926
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3MEF
<SEQUENCE>1
<FILENAME>d746379ds3mef.htm
<DESCRIPTION>S-3MEF
<TEXT>
Document 1 - file: d746379ds3mef.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>d746379dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: d746379dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>3
<FILENAME>d746379dex232.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 3 - file: d746379dex232.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.3
<SEQUENCE>4
<FILENAME>d746379dex233.htm
<DESCRIPTION>EX-23.3
<TEXT>
Document 4 - file: d746379dex233.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g746379p9a.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g746379p9a.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g746379p9b.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g746379p9b.jpg

</DOCUMENT>
</SEC-DOCUMENT>