Income Taxes - Deferred Assets and Liabilities, CFDs (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carryforwards	$ 120,361	$ 119,155
Capitalized start-up costs	3,469	3,812
Research and development tax credit carryforwards	21,954	20,505
Section 174 research and development capitalization	31,185	30,984
Capitalized research and development expense	2,145	2,359
Stockbased compensation expense	19,101	18,055
Accrued compensation	791	1,219
Lease liabilities	588	774
Deferred income	5,510
IPR&D	20,004
Other	408	407
Total deferred tax assets	225,516	197,270
Deferred tax liabilities:
Property and equipment	(56)	(187)
Right-to-use assets	(642)	(853)
Other	(458)	(1,106)
Total deferred tax liabilities	(1,156)	(2,146)
Valuation allowance	(224,360)	$ (195,124)	$ (184,688)
Domestic Tax Jurisdiction
Deferred tax liabilities:
Operating loss carryforwards	469,400
Domestic Tax Jurisdiction | Research Tax Credit Carryforward
Deferred tax liabilities:
Tax credit carryforward	21,900
State and Local Jurisdiction
Deferred tax liabilities:
Operating loss carryforwards	401,100
State and Local Jurisdiction | Research Tax Credit Carryforward
Deferred tax liabilities:
Tax credit carryforward	$ 100