Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Loss before income taxes
U.S. operations	$ (132,065)	$ (88,848)
Loss before income taxes	$ (132,065)	$ (88,848)
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Federal statutory income tax rate	(21.00%)	(21.00%)
State taxes, net of federal benefit	(2.10%)	(1.70%)
Impact of state rate changes	(1.10%)	17.70%
Research and development tax credits	(1.10%)	(5.90%)
Excess equity compensation tax benefit, net of officer limitation	0.80%	0.60%
Revaluation of contingent consideration	0.40%	(6.30%)
Non-deductible royalty payments	1.80%	4.30%
Change in deferred tax asset valuation allowance	22.10%	11.70%
Other	0.20%	0.20%
Effective income tax rate	0.00%	(0.40%)