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Stock-Based Awards (Details) - shares
12 Months Ended
Jan. 01, 2025
Dec. 31, 2024
Dec. 31, 2023
Nov. 30, 2024
Dec. 31, 2022
Sep. 30, 2015
Stock-based awards            
Options outstanding   6,721,967 6,419,455   5,167,164  
Stock Option Valuation            
Risk-free interest rate (as a percent)   3.91% 3.55%      
Expected term (in years)   6 years 6 years 2 months 12 days      
Expected volatility (as a percent)   81.62% 77.73%      
Expected dividend yield (as a percent)   0.00% 0.00%      
2017 Inducement Plan            
Stock-based awards            
Options outstanding   329,000        
2015 Equity Incentive Plan            
Stock-based awards            
Number of shares authorized           1,643,872
Number of shares available for grant   4,820,283        
Percentage increase to shares available for grant from common outstanding as of preceding December 31 (as a percent)   4.00%        
Additional shares available 4,314,004          
Options outstanding   5,548,563        
2015 Equity Incentive Plan | Restricted stock unit awards            
Stock-based awards            
Number of shares outstanding   2,096,151        
2012 Equity Compensation Plan            
Stock-based awards            
Number of shares available for grant   0        
Options outstanding   218,404        
Inducement Plan, 2024            
Stock-based awards            
Number of shares authorized       2,000,000    
Number of shares available for grant   1,194,000        
Options outstanding   626,000        
Number of shares outstanding   180,000