CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Total revenue	$ 6,761	$ 6,482	$ 4,227
Costs and expenses:
Cost of revenue	4,713	5,133	4,055
Research and development	43,813	29,338	64,165
General and administrative	23,619	20,530	27,827
Revaluation of contingent consideration	24,339	2,393	734
Goodwill impairment			18,504
Total costs and expenses	96,484	57,394	115,285
Loss from operations	(89,723)	(50,912)	(111,058)
Other expense, net	(1,142)	(424)	(2,484)
Loss from continuing operations before income taxes	(90,865)	(51,336)	(113,542)
Income tax benefit		(182)
Loss from continuing operations	(90,865)	(51,154)	(113,542)
Income (loss) from discontinued operations, net of tax		139	(47,812)
Net loss	$ (90,865)	$ (51,015)	$ (161,354)
Net loss per share, basic	$ (1.60)	$ (1.20)	$ (3.90)
Net loss per share, diluted	$ (1.60)	$ (1.20)	$ (3.90)
Weighted average common shares outstanding, basic	56,730,583	42,539,293	41,323,921
Weighted average common shares outstanding, diluted	56,730,583	42,539,293	41,323,921
Other comprehensive income (loss):
Unrealized gain (loss) on marketable securities, net of tax of $0	$ (229)	$ (2)	$ 28
Foreign currency translation adjustment	99	(26)	(25)
Total other comprehensive income (loss)	(130)	(28)	3
Comprehensive loss	(90,995)	(51,043)	(161,351)
Contract research
Total revenue	5,830	5,786	$ 4,227
Other revenue
Total revenue	$ 931	$ 696