CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue, net	$ 5,865	$ 3,676	$ 10,906	$ 4,794
Cost of revenue		1,181		2,148
Costs and expenses:
Cost of revenue (excludes amortization)	2,703	1,181	5,480	2,148
Research and development	17,622	13,984	37,541	27,590
Sales and marketing	7,177	12,368	17,008	23,601
General and administrative	7,990	8,121	16,180	14,381
Goodwill impairment	18,504		18,504
Amortization of definite-lived intangible	1,660		3,319
Total costs and expenses	55,656	35,654	98,032	67,720
Loss from operations	(49,791)	(31,978)	(87,126)	(62,926)
Other income (expense), net	(85)	760	(315)	1,479
Net loss	$ (49,876)	$ (31,218)	$ (87,441)	$ (61,447)
Net loss per share, basic and diluted	$ (1.21)	$ (1.01)	$ (2.12)	$ (1.99)
Weighted average common shares outstanding, basic and diluted (in shares)	41,274,808	30,944,899	41,261,808	30,915,577
Other comprehensive income (loss):
Unrealized gain on marketable securities, net of tax of $0	$ 30	$ 111	$ 64	$ 46
Foreign currency translation adjustments	27	28	13	12
Total other comprehensive income	57	139	77	58
Comprehensive loss	(49,819)	(31,079)	(87,364)	(61,389)
Product sales
Revenue, net	4,979	1,533	8,757	1,533
Contract research
Revenue, net	$ 886	1,143	$ 2,149	2,261
Other revenue
Revenue, net		$ 1,000		$ 1,000