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Stock-Based Awards (Details) - shares
3 Months Ended 44 Months Ended
Jan. 01, 2019
Mar. 31, 2019
Mar. 31, 2018
Sep. 14, 2015
Dec. 31, 2018
Jul. 31, 2017
Sep. 30, 2015
Stock-based awards              
Options granted (in shares)   28,500          
Options outstanding   4,182,584     4,282,081    
Stock Option Valuation              
Risk-free interest rate (as a percent)   2.53% 2.61%        
Expected term (in years)   6 years 3 months 18 days 6 years 3 months 18 days        
Expected volatility (as a percent)   101.70% 95.60%        
Expected dividend yield (as a percent)   0.00% 0.00%        
2017 Inducement Plan              
Stock-based awards              
Number of shares authorized           1,000,000  
2015 Equity Incentive Plan              
Stock-based awards              
Number of shares authorized             1,643,872
Number of shares available for grant   1,896,482          
Percentage increase to shares available for grant from common outstanding as of preceding December 31 (as a percent)   4.00%          
Additional shares available 1,648,429            
2012 Equity Compensation Plan              
Stock-based awards              
Number of shares available for grant   0          
Options granted (in shares)       1,140,524      
Options outstanding   948,761     948,761    
Vesting period (in years)   4 years          
Term of award (in years)   10 years