Stock-Based Awards - Compensation (Details) - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2017	Mar. 31, 2016
Stock-based compensation expense
Stock-based compensation expense	$ 3,153	$ 1,222
Unrecognized stock-based compensation cost, options	31,416
Unrecognized compensation, RSUs	$ 5,105
Weighted average recognition period unrecognized stock-based compensation cost (in years)	3 years 3 months 4 days
Research and development expense.
Stock-based compensation expense
Stock-based compensation expense	$ 1,217	421
General and administrative expense.
Stock-based compensation expense
Stock-based compensation expense	$ 1,936	$ 801
Restricted Stock Units (RSUs) [Member]
Stock-based compensation expense
Weighted average recognition period unrecognized stock-based compensation cost (in years)	2 years 7 months 28 days

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.F)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Unrecognized cost of unvested share-based awards, other than options, awarded to employees as compensation.

+ References

No definition available.

+ Details

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- Definition

Unrecognized cost of unvested options awarded to employees as compensation.

+ References

No definition available.

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