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Income Taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Loss before income taxes      
U.S. operations $ (40,597) $ (11,823) $ (8,517)
Foreign operations (7,482) (8,740)  
Loss before income taxes, Noncontrolling Interest, Total $ (48,079) $ (20,563) $ (8,517)
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Federal statutory income tax rate (34.00%) (34.00%) (34.00%)
State taxes, net of federal benefit (5.20%) (3.80%) (6.60%)
Foreign rate differential 3.20% 6.00%  
Permanent differences 1.80%    
Research and development tax credits (2.00%) (1.50%) (1.00%)
Change in deferred tax asset valuation allowance 36.20% 33.30% 41.60%