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Agreements Related to Intellectual Property (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
installment
item
shares
Sep. 30, 2015
USD ($)
License Agreement        
Upfront payment recorded as research and development expense $ 7,162 $ 9,407 $ 26,533 $ 12,937
Assignment Agreement and Finder's Services Agreement [Member] | A-101        
License Agreement        
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones 1,000   1,000  
Maximum additional payments owed upon achievement of second set of development milestones 4,500   $ 4,500  
Term of Agreement, Minimum     15 years  
Assignment Agreement and Finder's Services Agreement [Member] | A-101 | General and administrative expense.        
License Agreement        
Milestone payment     $ 300  
Stock Purchase Agreement [Member]        
License Agreement        
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones 18,000   18,000  
Maximum additional payments owed upon achievement of second set of development milestones 22,500   22,500  
Upfront payment recorded as research and development expense     $ 600  
Stock Issued During Period, Shares, Purchase of Assets | shares     159,420  
Amount Of Fixed Annual Payment     $ 100  
Number Of Products | item     3  
Stock Issued During Period, Value, Purchase of Assets     $ 2,355  
Number Of Payments | installment     6  
Period from first commercial product sale that royalties are owed (in years)     10 years  
Commercial License Agreement        
License Agreement        
Maximum additional payments owed upon achievement of second set of development milestones $ 11,600   $ 11,600  
Amount Of Fixed Annual Payment     $ 10  
Period from first commercial product sale that royalties are owed (in years)     10 years