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Agreements Related to Intellectual Property (Details)
$ in Thousands
3 Months Ended 6 Months Ended
Mar. 24, 2016
USD ($)
item
shares
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2016
USD ($)
installment
Jun. 30, 2015
USD ($)
License Agreement          
Upfront payment recorded as research and development expense   $ 9,836 $ 1,793 $ 19,371 $ 3,530
Assignment Agreement and Finder's Services Agreement [Member] | A-101          
License Agreement          
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones   1,000   1,000  
Maximum additional payments owed upon achievement of second set of development milestones   $ 4,500   $ 4,500  
Term of Agreement, Minimum       15 years  
Assignment Agreement and Finder's Services Agreement [Member] | A-101 | General and administrative expense.          
License Agreement          
Milestone payment       $ 300  
Stock Purchase Agreement [Member]          
License Agreement          
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones $ 18,000        
Maximum additional payments owed upon achievement of second set of development milestones $ 22,500        
Upfront payment recorded as research and development expense       600  
Stock Issued During Period, Shares, Purchase of Assets | shares 159,420        
Amount Of Fixed Annual Payment $ 100        
Number Of Products | item 3        
Stock Issued During Period, Value, Purchase of Assets       $ 2,355  
Number Of Payments | installment       6  
Period from first commercial product sale that royalties are owed (in years) 10 years        
Commercial License Agreement          
License Agreement          
Maximum additional payments owed upon achievement of second set of development milestones $ 11,600        
Amount Of Fixed Annual Payment $ 10        
Period from first commercial product sale that royalties are owed (in years) 10 years