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Agreements Related to Intellectual Property (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Aug. 27, 2015
Feb. 29, 2016
Nov. 30, 2015
Aug. 31, 2012
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
License Agreement              
Upfront payment recorded as research and development expense         $ 15,339 $ 6,507 $ 3,488
Assignment Agreement and Finder's Services Agreement [Member] | A-101              
License Agreement              
Milestone payment   $ 300         $ 400
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones         1,000    
Maximum additional payments owed upon achievement of second set of development milestones         4,500    
Term of Agreeement, Minimum       15 years      
License and collaboration agreement | Rigel | JAK inhibitors              
License Agreement              
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones $ 80,000            
Maximum additional payments owed upon achievement of second set of development milestones $ 10,000            
Upfront payment recorded as research and development expense         8,000    
Period from first commercial product sale that royalties are owed (in years) 10 years            
Commercial License Agreement | JAKPharm and Key Organics [Member] | Products Containing Specified Compounds [Member]              
License Agreement              
Maximum aggregate payments owed upon achievement of specified pre-commercialization milestones     $ 2,350        
Upfront payment recorded as research and development expense         $ 250    
Period from first commercial product sale that royalties are owed (in years)     10 years        
Written termination notice period     3 months        
Annual maintenance fee     $ 50