X0306 4 2023-02-01 0 0001557746 Aclaris Therapeutics, Inc. ACRS 0001875875 Manion Douglas J. C/O ACLARIS THERAPEUTICS, INC. 640 LEE ROAD, SUITE 200 WAYNE PA 19087 1 1 0 0 Pres and CEO Employee Stock Option (Right to Buy) 16.97 2023-02-01 4 A 0 378000 0.00 A 2033-01-31 Common Stock 378000 378000 D Restricted Stock Units 2023-02-01 4 A 0 108000 0.00 A Common Stock 108000 108000 D Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of January 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date. Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer. The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of January 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date. /s/ Mark Ballantyne, Attorney-in-Fact 2023-02-03