X0306 4 2022-02-01 0 0001557746 Aclaris Therapeutics, Inc. ACRS 0001781549 Loerop James C/O ACLARIS THERAPEUTICS, INC. 640 LEE ROAD, SUITE 200 WAYNE PA 19087 0 1 0 0 Chief Business Officer Employee Stock Option (Right to Buy) 11.58 2022-02-01 4 A 0 155000 0.00 A 2032-01-31 Common Stock 155000 155000 D Restricted Stock Units 2022-02-01 4 A 0 45000 0.00 A Common Stock 45000 45000 D Exercisable with respect to 25% of the shares subject to the option vesting in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares underlying these restricted stock units vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. /s/ Mark Ballantyne, Attorney-in-Fact 2022-02-01