X0306 4 2018-02-08 1 0001557421 Ignyta, Inc. RXDX 0001414894 Kuhlen Christian V C/O IGNYTA, INC. 4545 TOWNE CENTRE COURT SAN DIEGO CA 92121 0 1 0 0 General Counsel and Secretary Common Stock 2018-02-08 4 D 0 22019 27.00 D 0 D Stock Option (Right to Buy) 5.70 2018-02-08 4 D 0 160000 0.00 D 2026-07-04 Common Stock 160000 0 D Stock Option (Right to Buy) 5.60 2018-02-08 4 D 0 25000 0.00 D 2027-01-04 Common Stock 25000 0 D In connection with the acquisition of the Issuer by Roche Holdings, Inc. ("Parent") on February 8, 2018, and pursuant to the terms of the Agreement and Plan of Merger by and among the Issuer, Parent and Abingdon Acquisition Corp. ("Merger Sub") dated December 21, 2017, Merger Sub acquired all of the issued and outstanding shares of Common Stock (the "Shares") for a purchase price of $27.00 per Share (the "Merger"). In connection with the Merger described in footnote (1), this option became fully vested and was automatically canceled and terminated and the holder became entitled to receive an amount in cash, without interest and less the amount of any tax withholding, equal to the product of (1) the number of shares of Common Stock of the Issuer underlying such option multiplied by (2) the excess, if any, of $27.00 over the exercise price per share of such option. /s/ Christian Kuhlen 2018-02-12