Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues
Net sales	$ 5,257	$ 18,514	$ 29,299
License and other revenue	7,007	7,541	6,420
Total revenue	12,264	26,055	35,719
Cost of sales	1,332	3,485	3,731
Write-down of inventory	1,654	385	2,274
Gross profit	9,278	22,185	29,714
Operating expenses:
Research and development	40,777	35,840	33,558
Selling, general and administrative	37,057	105,880	104,740
Impairment of intangible asset			31,269
Gain on settlement of payable		(4,131)
Total operating expenses	77,834	137,589	169,567
Loss from operations	(68,556)	(115,404)	(139,853)
Other expense (income) :
Interest income	(132)	(38)	(10)
Interest expense	5,962	72,634	27,160
Loss on extinguishment of debt		11,176	2,934
Change in fair value of financial instruments	(2,096)	(4,380)	(1,494)
Gain on deconsolidation of subsidiary			(24,000)
Loss on equity method investment	7,599	13,625	2,776
Other expense (income)	6	(8)	(134)
Total other expense	11,339	93,009	7,232
Loss before income tax expense	(79,895)	(208,413)	(147,085)
Income tax expense (benefit)	(121)	342	(3)
Net loss	(79,774)	(208,755)	(147,082)
Deemed dividend on convertible preferred stock and Class E redeemable convertible units	1,918	21,733
Net loss attributable to common stockholders	$ (81,692)	$ (230,488)	$ (147,082)
Basic and diluted net loss per share of common stock	$ (1.42)	$ (9.74)	$ (18.10)
Weighted average basic and diluted shares of common stock outstanding	57,405,331	23,674,512	8,127,781