X0306 4 2022-09-16 0 0001556263 Syros Pharmaceuticals, Inc. SYRS 0001207405 TYSON TIMOTHY 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 1 0 0 0 Common Stock 2022-09-16 4 A 0 8000 0.00 A 8000 D Stock Option (right to buy) 7.349 2022-09-16 4 A 0 12000 0.00 A 2032-09-15 Common Stock 12000 12000 D The option becomes exercisable as to 16.66% of the shares underlying the award on the six month anniversary of the date of grant, with the remainder vesting in equal monthly installments until the third anniversary of the date of grant, subject to the reporting person's continued service as a director through each applicable vesting date. Amounts reported in this Form 4 reflect the 1-for-10 reverse stock split effected by the issuer on September 16, 2022. /s/ Todd Rosenthal, as attorney-in-fact 2022-09-19