<SEC-DOCUMENT>0001193125-20-176648-index.html : 20200623
<SEC-HEADER>0001193125-20-176648.hdr.sgml : 20200623
<ACCEPTANCE-DATETIME>20200623171636
ACCESSION NUMBER:		0001193125-20-176648
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20200623
DATE AS OF CHANGE:		20200623

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-239141
		FILM NUMBER:		20983122

	BUSINESS ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		35 CAMBRIDGE PARK DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02140

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>d942972d424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d942972d424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g942972g02n32.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g942972g02n32.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g942972g02n49.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g942972g02n49.jpg

</DOCUMENT>
</SEC-DOCUMENT>