X0306 4 2018-06-14 0 0001556263 Syros Pharmaceuticals, Inc. SYRS 0001575843 Nashat Amir C/O SYROS PHARMACEUTICALS, INC. 620 MEMORIAL DRIVE, SUITE 300 CAMBRIDGE MA 02139 1 0 0 0 Stock Option (right to buy) 12.95 2018-06-14 4 A 0 11000 0 A 2028-06-13 Common Stock 11000 11000 D The option becomes exercisable as to 50% of the shares underlying the award on the six month anniversary of the date of grant, with the remainder vesting in equal monthly installments until the first anniversary of the date of grant, subject to the reporting person's continued service as a director through each applicable vesting date. /s/Gerald E. Quirk, as attorney-in-fact 2018-06-15