<SEC-DOCUMENT>0001104659-18-053551-index.html : 20181016
<SEC-HEADER>0001104659-18-053551.hdr.sgml : 20181016
<ACCEPTANCE-DATETIME>20180824170235
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001104659-18-053551
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20180824

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
<TEXT>
Document 1 - file: filename1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g210114bgi001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g210114bgi001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g210114bgi002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g210114bgi002.jpg

</DOCUMENT>
</SEC-DOCUMENT>