<SEC-DOCUMENT>0001104659-18-053548-index.html : 20180824
<SEC-HEADER>0001104659-18-053548.hdr.sgml : 20180824
<ACCEPTANCE-DATETIME>20180824170020
ACCESSION NUMBER:		0001104659-18-053548
CONFORMED SUBMISSION TYPE:	10-K/A
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20171231
FILED AS OF DATE:		20180824
DATE AS OF CHANGE:		20180824

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		10-K/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37813
		FILM NUMBER:		181037576

	BUSINESS ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
<DOCUMENT>
<TYPE>10-K/A
<SEQUENCE>1
<FILENAME>a18-21011_110ka.htm
<DESCRIPTION>10-K/A
<TEXT>
Document 1 - file: a18-21011_110ka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-31.3
<SEQUENCE>2
<FILENAME>a18-21011_1ex31d3.htm
<DESCRIPTION>EX-31.3
<TEXT>
Document 2 - file: a18-21011_1ex31d3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-31.4
<SEQUENCE>3
<FILENAME>a18-21011_1ex31d4.htm
<DESCRIPTION>EX-31.4
<TEXT>
Document 3 - file: a18-21011_1ex31d4.htm

</DOCUMENT>
</SEC-DOCUMENT>