<SEC-DOCUMENT>0001104659-18-005471-index.html : 20180131
<SEC-HEADER>0001104659-18-005471.hdr.sgml : 20180131
<ACCEPTANCE-DATETIME>20180131161350
ACCESSION NUMBER:		0001104659-18-005471
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		9
CONFORMED PERIOD OF REPORT:	20180130
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20180131
DATE AS OF CHANGE:		20180131

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37813
		FILM NUMBER:		18562888

	BUSINESS ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
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<TYPE>8-K
<SEQUENCE>1
<FILENAME>a18-4004_28k.htm
<DESCRIPTION>8-K
<TEXT>
Document 1 - file: a18-4004_28k.htm

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<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
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<DESCRIPTION>EX-1.1
<TEXT>
Document 2 - file: a18-4004_2ex1d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>a18-4004_2ex5d1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: a18-4004_2ex5d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>4
<FILENAME>a18-4004_2ex99d1.htm
<DESCRIPTION>EX-99.1
<TEXT>
Document 4 - file: a18-4004_2ex99d1.htm

</DOCUMENT>
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<TYPE>EX-99.2
<SEQUENCE>5
<FILENAME>a18-4004_2ex99d2.htm
<DESCRIPTION>EX-99.2
<TEXT>
Document 5 - file: a18-4004_2ex99d2.htm

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<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g40042kgi001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g40042kgi001.jpg

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<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g40042kgi002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: g40042kgi002.jpg

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<TYPE>GRAPHIC
<SEQUENCE>8
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: g40042moi001.gif

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<TEXT>
Document 9 - file: g40042mmi001.jpg

</DOCUMENT>
</SEC-DOCUMENT>