<SEC-DOCUMENT>0001047469-18-000577-index.html : 20180202
<SEC-HEADER>0001047469-18-000577.hdr.sgml : 20180202
<ACCEPTANCE-DATETIME>20180202161457
ACCESSION NUMBER:		0001047469-18-000577
CONFORMED SUBMISSION TYPE:	S-3/A
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20180202
DATE AS OF CHANGE:		20180202

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-222634
		FILM NUMBER:		18570819

	BUSINESS ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3/A
<SEQUENCE>1
<FILENAME>a2234436zs-3a.htm
<DESCRIPTION>S-3/A
<TEXT>
Document 1 - file: a2234436zs-3a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.5
<SEQUENCE>2
<FILENAME>a2234436zex-4_5.htm
<DESCRIPTION>EX-4.5
<TEXT>
Document 2 - file: a2234436zex-4_5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>a2234436zex-5_1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: a2234436zex-5_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>a2234436zex-23_1.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 4 - file: a2234436zex-23_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g33281kqi001.gif
<DESCRIPTION>G33281KQI001.GIF
<TEXT>
Document 5 - file: g33281kqi001.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g33281kqi002.gif
<DESCRIPTION>G33281KQI002.GIF
<TEXT>
Document 6 - file: g33281kqi002.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g622400.jpg
<DESCRIPTION>G622400.JPG
<TEXT>
Document 7 - file: g622400.jpg

</DOCUMENT>
</SEC-DOCUMENT>