<SEC-DOCUMENT>0001047469-18-000528-index.html : 20180131
<SEC-HEADER>0001047469-18-000528.hdr.sgml : 20180131
<ACCEPTANCE-DATETIME>20180131161302
ACCESSION NUMBER:		0001047469-18-000528
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20180131
DATE AS OF CHANGE:		20180131

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Syros Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001556263
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453772460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-219369
		FILM NUMBER:		18562868

	BUSINESS ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-744-1340

	MAIL ADDRESS:	
		STREET 1:		620 MEMORIAL DRIVE
		STREET 2:		SUITE 300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LS22, Inc.
		DATE OF NAME CHANGE:	20120815
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>a2234424z424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: a2234424z424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g741323.jpg
<DESCRIPTION>G741323.JPG
<TEXT>
Document 2 - file: g741323.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g248548.jpg
<DESCRIPTION>G248548.JPG
<TEXT>
Document 3 - file: g248548.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g394581.jpg
<DESCRIPTION>G394581.JPG
<TEXT>
Document 4 - file: g394581.jpg

</DOCUMENT>
</SEC-DOCUMENT>