<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0707</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001556231</cik>
        <entityName>Reven Pharmaceuticals, Inc.</entityName>
        <issuerAddress>
            <street1>4411 BEE RIDGE ROAD</street1>
            <street2>SUITE 285</street2>
            <city>SARASOTA</city>
            <stateOrCountry>FL</stateOrCountry>
            <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
            <zipCode>34233</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>941-320-9271</issuerPhoneNumber>
        <jurisdictionOfInc>FLORIDA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Advanced Diagnostics International of Florida, Inc.</previousName>
            <previousName>Noventis, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName>B.</middleName>
                <lastName>Lange</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4411 Bee Ridge Road</street1>
                <street2>Suite 285</street2>
                <city>Sarasota</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>34233</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Denomme</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4411 Bee Ridge Road</street1>
                <street2>Suite 285</street2>
                <city>Sarasota</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>34233</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Handley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4411 Bee Ridge Road</street1>
                <street2>Suite 285</street2>
                <city>Sarasota</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>34233</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000897069-13-000270</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2013-02-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>5000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Futures Investment Company</recipientName>
                <recipientCRDNumber>42402</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>5914 North 300 West</street1>
                    <city>Fremont</city>
                    <stateOrCountry>IN</stateOrCountry>
                    <stateOrCountryDescription>INDIANA</stateOrCountryDescription>
                    <zipCode>46737</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>MI</state>
                    <description>MICHIGAN</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>WY</state>
                    <description>WYOMING</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>NE</state>
                    <description>NEBRASKA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2000000</totalOfferingAmount>
            <totalAmountSold>1833055</totalAmountSold>
            <totalRemaining>166945</totalRemaining>
            <clarificationOfResponse>The offering is completed.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>36</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>The Selling Agent will be compensated solely in Shares and has received 266,100 Shares and has earned 44,617 which have not yet been issued.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>54000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Reven Pharmaceuticals, Inc.</issuerName>
                <signatureName>Peter B. Lange</signatureName>
                <nameOfSigner>Peter B. Lange</nameOfSigner>
                <signatureTitle>President</signatureTitle>
                <signatureDate>2014-01-28</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
