Segment Information - Income Statement (Details) - USD ($) $ in Millions		12 Months Ended
		Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Segment Reporting Information [Line Items]
Revenues		$ 8,080	$ 7,776	$ 6,675
Cost of Sales	[1]	2,454	2,303	2,057
Other (income)/deductions-net		40	48	17
Earnings	[2]	2,656	2,488	1,996
Depreciation and Amortization	[2],[3]	465	448	441
Property, plant and equipment, less accumulated depreciation		2,753	2,422
Other business activities
Segment Reporting Information [Line Items]
Earnings		(424)	(406)	(372)
Depreciation and Amortization	[3]	28	28	27
United States
Segment Reporting Information [Line Items]
Revenues		4,313	4,042	3,557
Property, plant and equipment, less accumulated depreciation		1,820	1,638
International
Segment Reporting Information [Line Items]
Property, plant and equipment, less accumulated depreciation		933	784
Operating Segments
Segment Reporting Information [Line Items]
Earnings		4,753	4,517	3,786
Depreciation and Amortization	[3]	141	128	111
Operating Segments | United States Segment
Segment Reporting Information [Line Items]
Revenues		4,313	4,042	3,557
Cost of Sales		803	788	709
Gross Profit		$ 3,510	$ 3,254	$ 2,848
Gross Margin		81.40%	80.50%	80.10%
Operating Expenses		$ 765	$ 681	$ 602
Other (income)/deductions-net		(18)	(4)	(7)
Earnings		2,763	2,569	2,239
Depreciation and Amortization	[3]	55	54	55
Operating Segments | International Segment
Segment Reporting Information [Line Items]
Revenues	[4]	3,681	3,652	3,035
Cost of Sales		1,083	1,106	971
Gross Profit		$ 2,598	$ 2,546	$ 2,064
Gross Margin		70.60%	69.70%	68.00%
Operating Expenses		$ 611	$ 602	$ 510
Other (income)/deductions-net		3	4	(7)
Earnings		1,990	1,948	1,547
Operating Segments | International
Segment Reporting Information [Line Items]
Depreciation and Amortization	[3]	86	74	56
Corporate, Non-Segment
Segment Reporting Information [Line Items]
Earnings		(1,073)	(1,052)	(879)
Depreciation and Amortization	[3]	132	115	101
Segment Reconciling Items
Segment Reporting Information [Line Items]
Depreciation and Amortization	[3]	0	0	0
Purchase accounting adjustments, earnings		(160)	(175)	(198)
Purchase accounting adjustments, depreciation and amortization	[3]	159	175	199
Acquisition-related costs, earnings		(5)	(12)	(18)
Certain significant items, earnings	[5]	(56)	(73)	(43)
Certain significant items, depreciation and amortization	[3],[5]	0	0	0
Other unallocated, earnings		(379)	(311)	(280)
Other unallocated, deprecation and amortization	[3]	$ 5	$ 2	$ 3

[1] Exclusive of amortization of intangible assets, except as disclosed in Note 3. Significant Accounting Policies—Amortization of Intangible Assets, Depreciation and Certain Long-Lived Assets.

[2] Defined as income before provision for taxes on income.

[3] Certain production facilities are shared. Depreciation and amortization is allocated to the reportable operating segments based on estimates of where the benefits of the related assets are realized.

[4] Revenue denominated in euros was $774 million in 2022, $814 million in 2021 and $718 million in 2020.

[5] For 2022, certain significant items primarily represents inventory and asset impairment charges related to customer relationships, developed technology rights and property, plant and equipment in our diagnostics, poultry, cattle and swine businesses and the consolidation of manufacturing sites in China of $47 million, as well as employee termination and exit costs associated with cost-reduction and productivity initiatives in certain international markets of $4 million. For 2021, certain significant items primarily included certain asset impairment charges of $46 million, as well as employee termination costs associated with our international operations and other costs associated with cost-reduction and productivity initiatives of $24 million. For 2020, certain significant items primarily included certain asset impairment charges of $37 million and CEO transition-related costs of $16 million, partially offset by a net gain resulting from a cash payment received pursuant to an agreement related to the 2016 sale of certain U.S. manufacturing sites of $18 million.