Segment Information (Tables)

12 Months Ended

Dec. 31, 2022

Segment Reporting [Abstract]

Schedule of Selected Income Statement Information by Segment

Selected Statement of Income Information                                 

	Earnings									Depreciation and Amortization(a)
	Year Ended December 31,									Year Ended December 31,
(MILLIONS OF DOLLARS)	2022			2021			2020			2022		2021		2020
U.S.
Revenue	$	4,313		$	4,042		$	3,557
Cost of Sales	803			788			709
Gross Profit	3,510			3,254			2,848
Gross Margin	81.4		%	80.5		%	80.1		%
Operating Expenses	765			681			602
Other (income)/deductions-net	(18)			4			7
U.S. Earnings	2,763			2,569			2,239			$	55	$	54	$	55
International
Revenue(b)	3,681			3,652			3,035
Cost of Sales	1,083			1,106			971
Gross Profit	2,598			2,546			2,064
Gross Margin	70.6		%	69.7		%	68.0		%
Operating Expenses	611			602			510
Other (income)/deductions-net	(3)			(4)			7
International Earnings	1,990			1,948			1,547			86		74		56
Total operating segments	4,753			4,517			3,786			141		128		111
Other business activities	(424)			(406)			(372)			28		28		27
Reconciling Items:
Corporate	(1,073)			(1,052)			(879)			132		115		101
Purchase accounting adjustments	(160)			(175)			(198)			159		175		199
Acquisition-related costs	(5)			(12)			(18)			—		—		—
Certain significant items(c)	(56)			(73)			(43)			—		—		—
Other unallocated	(379)			(311)			(280)			5		2		3
Total Earnings(d)	$	2,656		$	2,488		$	1,996		$	465	$	448	$	441

(a)    Certain production facilities are shared. Depreciation and amortization is allocated to the reportable operating segments based on estimates of where the benefits of the related assets are realized.

(b)    Revenue denominated in euros was $774 million in 2022, $814 million in 2021 and $718 million in 2020.

(c)    For 2022, certain significant items primarily represents inventory and asset impairment charges related to customer relationships, developed technology rights and property, plant and equipment in our diagnostics, poultry, cattle and swine businesses and the consolidation of manufacturing sites in China of $47 million, as well as employee termination and exit costs associated with cost-reduction and productivity initiatives in certain international markets of $4 million.

For 2021, certain significant items primarily included certain asset impairment charges of $46 million, as well as employee termination costs associated with our international operations and other costs associated with cost-reduction and productivity initiatives of $24 million.

For 2020, certain significant items primarily included certain asset impairment charges of $37 million and CEO transition-related costs of $16 million, partially offset by a net gain resulting from a cash payment received pursuant to an agreement related to the 2016 sale of certain U.S. manufacturing sites of $18 million.

    (d)    Defined as income before provision for taxes on income.

Long-lived Assets by Geographic Areas

Property, plant and equipment, less accumulated depreciation, by geographic region follow:

	As of December 31,
(MILLIONS OF DOLLARS)	2022		2021
U.S.	$	1,820	$	1,638
International	933		784
Property, plant and equipment, less accumulated depreciation	$	2,753	$	2,422