Revenue - Revenue by Major Species (Details) - USD ($) $ in Millions	3 Months Ended				9 Months Ended
	Sep. 30, 2022		Sep. 30, 2021		Sep. 30, 2022		Sep. 30, 2021
Revenue from External Customer [Line Items]
Revenue	$ 2,002		$ 1,990		$ 6,040		$ 5,809
Contract manufacturing & human health
Revenue from External Customer [Line Items]
Revenue	23		21		59		57
Companion animal
Revenue from External Customer [Line Items]
Revenue	1,271		1,202		3,900		3,507
Companion animal | U.S.
Revenue from External Customer [Line Items]
Revenue	819		775		2,488		2,227
Companion animal | International
Revenue from External Customer [Line Items]
Revenue	452		427		1,412		1,280
Livestock
Revenue from External Customer [Line Items]
Revenue	708		767		2,081		2,245
Livestock | U.S.
Revenue from External Customer [Line Items]
Revenue	271		290		713		775
Livestock | International
Revenue from External Customer [Line Items]
Revenue	437		477		1,368		1,470
Operating Segments | U.S.
Revenue from External Customer [Line Items]
Revenue	1,090		1,065		3,201		3,002
Operating Segments | International
Revenue from External Customer [Line Items]
Revenue	$ 889	[1]	$ 904	[1]	$ 2,780	[2]	$ 2,750	[2]

[1] Revenue denominated in euros was $183 million and $204 million for the three months ended September 30, 2022 and 2021, respectively.

[2] Revenue denominated in euros was $590 million and $605 million for the nine months ended September 30, 2022 and 2021, respectively.