Share-Based Payments (Stock option activity) (Details) - USD ($) $ / shares in Units, $ in Millions		12 Months Ended
		Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Shares
Outstanding, Beginning Balance (in shares)		2,554,451
Granted (in shares)		284,198
Exercised (in shares)		(680,970)
Forfeited (in shares)		(25,112)
Outstanding, Ending Balance (in shares)		2,132,567	2,554,451
Weighted-average Exercise Price Per Share
Outstanding, Beginning Balance (in dollars per share)		$ 64.43
Granted (in dollars per share)		160.73
Exercised (in dollars per share)		52.88
Forfeited (in dollars per share)		80.72
Outstanding, Ending Balance (in dollars per share)		$ 80.19	$ 64.43
Outstanding, Weighted-average Remaining Contractual Term (in years)		5 years 4 months 24 days
Outstanding, Aggregate Intrinsic Value	[1]	$ 349
Exercisable, December 31, 2021		1,176,959
Exercisable, Weighted Average Exercise Price Per Share		$ 42.78
Exercisable, Weighted Average Remaining Contractual Term (in years)		3 years 3 months 18 days
Vested and expected to vest, Aggregate Intrinsic Value	[1]	$ 237
Weighted-average grant date fair value per stock option		$ 37.81	$ 34.22	$ 21.84
Aggregate intrinsic value on exercise		$ 87	$ 114	$ 76
Cash received upon exercise		36	57	39
Share-based Payment Arrangement, Exercise of Option, Tax Benefit		$ 34	$ 39	$ 31

[1] Market price of underlying Zoetis common stock less exercise price.