Revenue - Revenue by Species (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue from External Customer [Line Items]
Revenues	$ 7,776	$ 6,675	$ 6,260
Cattle
Revenue from External Customer [Line Items]
Revenues	1,557	1,558	1,654
Swine
Revenue from External Customer [Line Items]
Revenues	659	621	611
Poultry
Revenue from External Customer [Line Items]
Revenues	507	537	559
Fish
Revenue from External Customer [Line Items]
Revenues	187	148	134
Other
Revenue from External Customer [Line Items]
Revenues	95	76	72
Livestock
Revenue from External Customer [Line Items]
Revenues	3,005	2,940	3,030
Dogs and Cats
Revenue from External Customer [Line Items]
Revenues	263	215	195
Horses
Revenue from External Customer [Line Items]
Revenues	4,426	3,437	2,950
Companion Animal
Revenue from External Customer [Line Items]
Revenues	4,689	3,652	3,145
Contract Manufacturing and Human Health Diagnostics [Member]
Revenue from External Customer [Line Items]
Revenues	$ 82	$ 83	$ 85