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Segment Information (Tables)
12 Months Ended
Dec. 31, 2021
Segment Reporting [Abstract]  
Schedule of Selected Income Statement Information by Segment
Selected Statement of Income Information                                 
Earnings
Depreciation and Amortization(a)
Year Ended December 31,Year Ended December 31,
(MILLIONS OF DOLLARS)202120202019202120202019
U.S.
Revenue$4,042 $3,557 $3,203 
Cost of Sales788 709 655 
Gross Profit3,254 2,848 2,548 
    Gross Margin80.5 %80.1 %79.6 %
Operating Expenses681 602 543 
Other (income)/deductions-net4 — 
U.S. Earnings2,569 2,239 2,005 $54 $55 $44 
International
Revenue(b)
3,652 3,035 2,972 
Cost of Sales1,106 971 925 
Gross Profit2,546 2,064 2,047 
    Gross Margin69.7 %68.0 %68.9 %
Operating Expenses602 510 560 
Other (income)/deductions-net(4)— 
International Earnings1,948 1,547 1,487 74 56 53 
Total operating segments4,517 3,786 3,492 128 111 97 
Other business activities
(406)(372)(348)28 27 24 
Reconciling Items:
Corporate
(1,052)(879)(755)115 101 69 
Purchase accounting adjustments
(175)(198)(234)175 199 219 
Acquisition-related costs
(12)(18)(43) — — 
Certain significant items(c)
(73)(43)(67) — — 
Other unallocated
(311)(280)(244)2 
Total Earnings(d)
$2,488 $1,996 $1,801 $448 $441 $412 
(a)    Certain production facilities are shared. Depreciation and amortization is allocated to the reportable operating segments based on estimates of where the benefits of the related assets are realized.
(b)    Revenue denominated in euros was $814 million in 2021, $718 million in 2020 and $742 million in 2019.
(c)    For 2021, certain significant items primarily included certain asset impairment charges of $46 million, as well as employee termination costs associated with our international operations and other costs associated with cost-reduction and productivity initiatives of $21 million.
For 2020, certain significant items primarily included certain asset impairment charges of $37 million and CEO transition-related costs of $16 million, partially offset by a net gain resulting from a cash payment received pursuant to an agreement related to the 2016 sale of certain U.S. manufacturing sites of $18 million.
For 2019, certain significant items primarily includes: (i) a change in estimate related to inventory costing of $69 million, (ii) CEO transition-related costs of $10 million, (iii) consulting fees, product transfer costs, employee termination costs and exit costs related to cost-reduction and productivity initiatives of $7 million, and (iv) income of $20 million resulting from a cash payment received pursuant to an agreement related to the 2016 sale of certain U.S. manufacturing sites.
    (d)    Defined as income before provision for taxes on income.
Long-lived Assets by Geographic Areas Property, plant and equipment, less accumulated depreciation, by geographic region follow:
As of December 31,
(MILLIONS OF DOLLARS)20212020
U.S.$1,638 $1,486 
International784 716 
Property, plant and equipment, less accumulated depreciation$2,422 $2,202